Antonio Conte's side have been dominant all season, but slipped up on Saturday in a 2-1 defeat vs. Crystal Palace.
"When you are lucky enough to fight for the title there is the pressure, but not only for us, for a lot of teams".
Jesus' campaign looked to have abruptly ended when he suffered a metatarsal injury during the 2-0 victory over the Cherries on February 13, but it appears he could be back before the end of the season.
They are now 18 points behind leaders Chelsea but the Nigerian thinks that the Gunners can still be in the mix. Their last home win against the Manchester side in the league was in 2013.
Guardiola, clearly poised for a busy summer transfer window, said: "We will think about it, we will discuss with the chairman, Txiki, all the bosses".
"We should keep our heads up and think ahead for the next game since it will be very important".
Both teams have plenty on the line, with Chelsea looking to seal the Premier League title and Manchester City aiming to maintain their top four status.
"They play less games, they have more time to prepare", said Guardiola.
"What happened in that game happened many, many things".
He said: "For Chelsea, the focus they have is to win the title".
Conte said: "I don't know if he will be available, but we have another day to check this situation in the right way".
First meeting of the season between these two teams on Etihad went Chelsea's way, 3:1 on December 16 but the last match in the league on Stamford Bridge went Manchester City's way, 0:3 on April 16 past year.
After a hard-earned point at Arsenal on Sunday, Manchester City prepare to face another London giant on Wednesday, league leaders Chelsea.
The Brazil global has been working in the gym in a bid to keep up his fitness levels and it is hoped he can return to full training soon - and feature for the first team before the end of the season.
Paul Clement's side have lost the momentum they were picking up at the start of 2017, picking up only one point from their last three games. Currently, they rank fourth in the league table with 58 points in 29 games and are undefeated in the last eight consecutive games with 4-4-0 record including 3-1-0 record in last four away games. "Fernandinho is not one of those guys who is aggressive, he is one of the sweetest and nicest guys I have ever met. Sergio and Fernandinho are nice guys".