Israel has previously targeted Syria after fire landed in the Golan Heights and to strike weapon supplies of Lebanon's Hezbollah group, which supports the Syrian government in the current conflict, Reuters said.
The Israeli army said the so-called retaliatory strikes targeted Syrian positions north of Golan Heights where rockets were allegedly fired from on Israeli territories.
The military stated that the errant projectiles were the result of internal fighting in Syria.
Israel attacked several Syrian military targets in response to at least 10 mortar rounds that landed in the Golan Heights. Two people were reportedly killed in Quneitra in the attack, Syrian media reported.
Intense fighting has rocked the Quneitra province of Syria, adjacent to the Golan Heights, since rebels there launched an attack on Saturday.
The Syrian Observatory for Human Rights, which monitors events in the war-torn country, said Israeli forces had fired missiles causing casualties among regime troops and loyal militias. Israel said it responded with airstrikes on the position the mortars came from and took out two Syrian army tanks, including one as it was preparing to fire.
IDF aircraft hit several targets at Syrian army installations in the Golan, destroying buildings and tanks.
Damascus says Israel and its Western and regional allies are aiding Takfiri terrorist groups operating inside the Arab country, while the Tel Aviv regime's military carries out sporadic strikes against Syrian government forces. "We will respond strongly to any attack on our territory or our citizens", he said.
Opposing factions in Syria's civil war have been battling heavily in the Kuneitra area adjacent to Israel's northern border, and the fire that hit Israel is estimated to be stray.