With only two women's matches scheduled for Wimbledon's two main show-courts on Monday, Kerber was exiled to the less grand Court Two.
It is also worth noting that Williams made her Grand Slam debut all the way back in 1997, which was seven months before her opponent in Konjuh was even born. "Winning never gets old at any stage in your career, ever, ever". "I think I'm playing pretty solid".
"You'll have to ask me when I'm retired, what it feels like", she said.
Williams, who won the most recent of her singles titles here in 2008, beat the 27th seed 6-3 6-2 on Centre Court.
She will be replaced at number one by either Karolina Pliskova or Simona Halep.
Williams becomes the oldest player since then 37-year-old Martina Navratilova in 1994 to reach the quarter-finals, where she will face the brightest of the sport's next-generation stars, French Open champion Jelena Ostapenko. In an impressive follow-up to her stunning French Open title, she defeated No. 5-ranked Elina Svitolina of Ukraine on Monday, 6-3, 7-6 (6).
The number ten seed is the only previous victor remaining in this year's tournament, although the last of her five titles at the All-England Club came back in 2008.
American Coco Vandeweghe, the 24th seed, has an attacking game perfectly suited to the grass and strode on with an impressive 7-6 (7/4) 6-4 victory over Danish fifth seed Caroline Wozniacki.