Brighton may have conceded large swathes of possession to Pep Guardiola's men, but Albion clung on for over an hour before City finally broke the deadlock.
The south-coast side fell further behind in the 75th minute when Lewis Dunk, under pressure from Gabriel Jesus, headed Fernandinho's cross into his own net in Brighton's first game in the top-flight in 34 years.
After claiming second place in the Championship last season, the Seagulls welcomed City to the Amex Stadium for the curtain raiser they had all been waiting for. He has now scored five goals in six opening day matches for City.
"We bought three and the market is so demanding right now, for all the teams around the world, not just for Manchester City". Being at one club for eight, nine years it's a big change for me but I'm enjoying my football. The new players that come in they have to adjust to the way we want to play.
"But the season is going to be long and today was an improvement on a lot of things we did last season".
"I am old enough to remember the last (and only) time we were in the old First Division, from 1979 to 1983".
Guardiola said: "Hopefully next season I will be here and we are not going to spend how we spent this season".
"We can take a lot of positives from the game".
"Like every club that's promoted to the Premier League, it's to finish 17th or higher".
"We know better, I know better and they know me better".
"We have to learn to attack better if teams play in that way, the big teams have to handle those situations". I saw him on the TV last season, but it will depend on how he and the other players adjust to the Premier League. "We got the goal because we were patient". But we have to improve.
"There's a huge gulf between the Championship and the top Premier League teams and having watched City in pre-season, they look like they are in the mood for a good start. That's the quality that they've got".
Guardiola's side have been installed as title favourites but the former Barcelona boss is not taking anything for granted and anticipates a tough start.