Wenger has confirmed that playmaker Mesut Ozil and midfielder Aaron Ramsey will not play, citing residual fatigue from last week's global matches.
"On the injury front we have no big problems, but a few players have some response to playing two global games - like Ozil and Ramsey, who are rested completely", Wenger told a news conference on Wednesday.
Meanwhile, the likes of David Ospina, Jack Wilshere and Theo Walcott are all in contention to make their first start of the season. At Chelsea, we were really disappointed to have been knocked of the group stage [of the UEFA Champions League] but we decided that for the first time and the last time, hopefully, we play in the Europa League so we want to win.
After a poor start to the season Hector Bellerin believes that Arsenal should take inspiration in what Chelsea achieved last season from a similar start.
Giroud's next goal will be his 100th in Arsenal colours after he netted his 99th in the 4-3 victory over Leicester in the first game of the new Premier League season.
Francis Coquelin will also miss the tie and will be out for the next three weeks after injuring his hamstring against Bournemouth on Saturday.
"It is not the best chance but one of the opportunities", he said.
Hector Bellerin insists Arsenal should not be ruled out of winning the Premier League despite enduring a hard start to the season.
"He had been out so many times after suffering bad tackles and had just come back from a fracture".
"It has been a hard period for the Arsenal family".
"We made 75 points a year ago and overall I am humble enough to be happy enough to win every single competition".
"So as I said to the boss our story was not finished, and everybody was pleased with that".