The Los Angeles County Sheriff's Department was working to evacuate residents near the area of Lopez Canyon and Kagel Canyon, according to LA County Fire. The fire is northeast of the Getty Center and east of the San Diego Freeway.
The blaze comes amid a red flag warning - due to low humidity and fierce Santa Ana winds - that is expected to last through much of the week.
Santa Paula and both the county and city of Ventura have also declared local emergencies, according to officials.
Fire crews on Tuesday evening continued to battle a series of rapidly moving conflagrations in the Los Angeles area.
Share this article: A firefighter uses a fire hose on a past blaze.
As the fire expanded and jumped south of the 210 Freeway, so did the mandatory evacuation area.
More than 125 firefighters were on the scene and that water-dropping helicopters were being used, the newspaper said. The Skirball Fire encompasses parts of Bel Air, Holmby Hills, and Brentwood, and is affecting the surrounding food-friendly neighborhoods, including Westwood. The owner had been ordered to evacuate at 5 a.m. this morning with homes in the 1300 address range reportedly on fire.
Evacuation centers are open at the Sylmar Recreation Center, located at 13109 Borden Avenue. Winds in the area were blowing at 25 miles per hour.
"Driving to LAX just as they're closing the 405 for this roaring hillside fire near the Getty exit", Rebecca Keegan, the Vanity Fair correspondent tweeted Wednesday.
The new blaze shut down the 405 Freeway between the 101 and 10 freeways.
Police were forced to shut down nine miles of the Interstate 405 freeway, one of the busiest in the USA, early on Wednesday morning.
About 9 a.m., the southbound freeway was reopened, but some onramps and offramps remained closed in the area, as was a section of Mulholland Drive, the CHP reported.